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ME affects some 250,000 Britons and is more common in women than men.
It had higher levels of various compounds released by the immune system to defend the body against infection.
The link with an immune protein, interferon gamma, was particularly strong, the journal Science Advances reports.
She also suffered migraines, dizziness and digestion problems.
But doctors merely gave her painkillers and told her to rest.
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In desperation her husband, fellow musician Chris Marshall – whom she had married the previous year – took her to A&E, where Miss Jones suffered a seizure.