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  1. Hinschius, "Das Kirchenrecht der Katholiken und Protestanten in Deutschland", Berlin, 1869, I, 318 sqq.). The "Liber Pontificalis" describes as follows this quasi-parochial system of ancient Rome: "Hic [Euaristus, 99-107? 2 (Concilium apocryphum Silvestri I, about the end of the fifth century), C. LXXXIX; Letter of Leo IX (1053) to Michael Cærularius in Jaffé, "Regesta Pontificum Romanorum", 2d ed. We read in this constitution "De jure cardinalium" as follows: "Itemque ex nostrâ præsenti constitutione his in mense vel eo amplius vel apud illum vel illum titulum sive apud illam vel illam diaconiam sive apud alias quasilibet ecclesias vos convenire mandamus, et ob vestram et inferiorum clericorum vitam et mores et qualitates et habitus vestium perscrutandum et qualiter quilibet præpositi se erga subditos habeant vel quod subditi suis præpositis non obediant et ad quæque illicita amputanda, clericorum quoque et laicorum querimonias, quæ ad nostrum judicium pertinent, quantum fieri potest definiendas, quippe cum sicut nostram mansuetudinem Moysi, ita et vestram paternitatem LXX seniorum, qui sub eodem causarum negotia diiudicabant, vicissitudinem gerere, certum habeamus. That is, the pope commands them to meet at least twice a month, in their own or other churches, to investigate their own lives and those of the clergy, the relations of superiors and inferiors, and in general to check all violations of the laws; also to settle, as far as is possible in the papal court, all conflicts between laymen and ecclesiastics. These eighteen deacons have each a church of Rome; they are also, adds Johannes Diaconus, canons of the Lateran Basilica. In all such cases the recipient must promise under oath, and under pain of nullity of his nomination, that within a year he will go personally to Rome for the further ceremonies above described, and to receive his "title" (Postquam verus, § 19).

  2. White et al 38 reported the synthesis of hydroxamates using Deoxo-fluor; Katritzky et al 39 reported the synthesis of N-alkyl, O-alkyl and O, N-dialkyl hydroxamic acids via acyl benzotriazole intermediates; Gissot et al 40 reported high yielding one step synthesis of hydoxamates from various un-activated esters including enolizable esters and chrial α-amino acid esters and peptides ; Woo et al 41 reported the conversion of sterically hindered carboxylic acids to N-methoxy-N-methyl amides using 1.1eq of methanesulphonyl chloride; Martinelli et al 42 reported the palladium catalysed amino carbonylation of anyl bromides into the corresponding Weinreb amides; Nemoto et al 43 also reported a one pot synthesis of α-siloxy weinreb amides from aldelydes using N, O-dimethly amine and a masked acyl cyamide reagent bearing a tert-butyl dimethyl silyl group. Synthesis of Anticancer Hydroxamates Most hydroxamates used in cancer chemotherapy acts as histone deacetylase HDAC inhibitors.